LAKESIS® (0.2%) – An extract of the ‘tears of Chios’, obtained from the resin of the mastic tree. In the supplier’s studies, the activity of Lakesis is directed at stimulating the expression of proteins responsible for stress resistance, cellular detoxification and DNA repair. This enhances the regenerative potential of the skin, improves collagen synthesis and helps restore its density and firmness. It is against the background of declining oestrogen levels that the skin loses volume and begins to ‘sag’. By promoting increased synthesis of type I and type III collagen, Lakesis acts as a lipofilling-like active that restores density and definition to the facial contour.
The extract is rich in polyphenols, which neutralise reactive oxygen species (ROS). The expression of inflammatory cytokines (IL-6, TNF-α) is suppressed, which helps counteract the visible effects of chronic low-grade inflammation (‘inflammaging’). Collagen degradation is reduced through inhibition of metalloproteinase activity (MMP-1, MMP-9). The balance between protein synthesis and degradation is maintained in the dermis.
Lakesis actively stimulates the expression of the ‘youth genes’ Klotho and FOXO, which are responsible for extending the lifespan of cells and their resistance to stress.
Klotho is a transmembrane and circulating protein that regulates antioxidant pathways and prolongs the viability of fibroblasts. Its activation reduces the level of oxidative stress and supports the longevity of dermal cells, helping to slow their premature ageing.
FOXO is a transcription factor that triggers the expression of antioxidant defence genes (catalase, superoxide dismutase) and of DNA repair genes. For the skin this means protection of fibroblasts and keratinocytes against damage by free radicals and UV radiation. Dermal cells retain their metabolic activity for longer and continue to synthesise structural proteins (collagen I and III, elastin, fibrillin). As a result the collagen and elastin framework is reinforced, and skin density and firmness increase through stimulation of fibrillin-1 and collagen synthesis in dermal fibroblasts.

LAPAGYL™ (2%) – An extract of the bark of the lapacho tree (the ‘tree of life’). The extract is rich in naphthoquinones (lapachol, beta-lapachone), polyphenols and flavonoids – molecules with pronounced bioregulatory and antioxidant activity. Lapagyl helps support telomere stability through its antioxidant and soothing properties (reducing oxidative stress and inflammatory signals, which extends the life cycle of epidermal cells). This maintains the skin’s capacity for renewal and slows the formation of age-related changes.
With age, skin cells enter a state of senescence (they stop dividing but release inflammatory factors → SASP). In the supplier’s in-vitro studies, the active components of Lapagyl™ modulate the p53/p21 and p16INK4a signalling pathways, which reduces the accumulation of senescent cells, stimulates the division of still-functional fibroblasts and reduces the secretion of pro-inflammatory cytokines by senescent cells. As a result, markers of the ‘biological age’ of the tissue decrease and cells retain their capacity for renewal for longer.
Lapagyl is active against ageing and skin damage caused by UV radiation: it reduces levels of reactive oxygen species (ROS), protects the cells of the basal and spinous layers against damage, and has a soothing effect, reducing CCL8 expression and slowing the formation of FOXP3+ regulatory T cells under the influence of UV radiation.

SOLINE® (2%) – A ceramide booster: a fraction of unsaponifiable sunflower lipids, particularly rich in the essential linoleic acid (ω-6 PUFA). Linoleic acid is metabolised into lipid mediators associated with skin comfort (PGE1, 15-HETrE); the production of pro-inflammatory cytokines in keratinocytes (IL-1α, IL-6) decreases, and irritation and visible redness are reduced.
Linoleic acid is an essential substrate for the enzyme ceramide synthase (CerS). Under the action of Soline®, ceramide synthesis in keratinocytes is activated.
Levels of ceramide EOS and NP – key to the formation of the lipid layers of the stratum corneum – increase. As a result the lamellar structure of the intercellular lipids is restored. Ceramides + cholesterol + free fatty acids form a kind of ‘cement’ that binds the corneocytes together. Provided their levels are sufficient, transepidermal water loss decreases, barrier function is reinforced and the skin becomes less sensitive to irritants. Histologically: a more compact stratum corneum, fewer microfissures and fewer disruptions in the lipid layers.

VITAMIN COMPLEX: VITAMIN E (0.5%) + VITAMIN C (1%) – The lipophilic form of vitamin C together with vitamin E provides long-lasting neutralising action against free radicals, protects cell membranes and enhances collagen synthesis, improving skin firmness and density.
Vitamin E neutralises lipophilic free radicals, terminating peroxide chain reactions in membranes. Vitamin C reduces ROS levels and is also able to regenerate oxidised vitamin E, restoring its antioxidant activity. The skin thus receives a ‘double shield’ against oxidative stress (UV radiation, pollutants).
Vitamin C is a cofactor of the enzymes prolyl and lysyl hydroxylase, which stabilise the triple helix of collagen. Without a sufficient level of vitamin C, collagen fibres form defectively.
Vitamin E protects fibroblast membranes against peroxidation, preserving their functionality.
Together they support the synthesis of higher-quality collagen and slow the breakdown of the dermal framework.

INCI: Helianthus Annuus (Sunflower) Seed Oil, Octyldodecanol, Dicaprylyl Carbonate, Coco-Caprylate/Caprate, Caprylic/Capric Triglyceride, C15-19 Alkane, Helianthus Annuus (Sunflower) Seed Oil Unsaponifiables, Brassica Campestris (Rapeseed) Seed Oil, Parfum (Fragrance), Ascorbyl Tetraisopalmitate, Tocopheryl Acetate, Tabebuia Impetiginosa Bark Extract, Polyglyceryl-3 Diisostearate, Tetramethyl Acetyloctahydronaphthalenes, Pistacia Lentiscus (Mastic) Gum, Tocopherol

Apply to cleansed skin before a mask or cream. If required, a light massage may be performed over the serum for more intensive penetration of the active ingredients.